标签归档：par

多肽定制PAR-2 Agonis,Protease-Activated Receptor-2 Agonist amide 编码

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名称 PAR-2 Agonis,Protease-Activated Receptor-2 Agonist amide
编码
别名 PAR-2 Agonis,Protease-Activated Receptor-2 Agonist amide
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） SLIGKV-NH2
序列（三字母缩写） H-Ser-Leu-Ile-Gly-Lys-Val-NH2?(trifluoroacetate salt)
基本描述
溶解度
分子量 614.8
化学式 C28H54N8O7
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents PAR-2 Agonis,Protease-Activated Receptor-2 Agonist amide 编码
Figures PAR-2 Agonis,Protease-Activated Receptor-2 Agonist amide 编码
Reference Dulon et al. Am. J. Resp. Cell Mol. Biol. 28, 339 (2003) Kim, M. et al. Cell Biochem. Funct. 20, 339 (2002) Vesey, D. et al. Kidney International 67, 1315 (2005) Hollenberg, M. Can. J. Physiol. Pharmacol. 75, 832 (1997) Nishikawa, H. et al. J. Pharmacol. Exp. Ther. 312, 324 (2005)
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多肽定制(Ala1)-PAR-4 (1-6)) amide (mouse)|[Ala1]-Protease Activated Receptor-4 (1-6) amide, mouse 编码 [352017-71-1]

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名称 (Ala1)-PAR-4 (1-6)) amide (mouse)|[Ala1]-Protease Activated Receptor-4 (1-6) amide, mouse
编码 [352017-71-1]
别名 (Ala1)-PAR-4 (1-6)) amide (mouse)|[Ala1]-Protease Activated Receptor-4 (1-6) amide, mouse
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） AYPGKF-NH2
序列（三字母缩写） H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2
基本描述 The peptide is the minimal peptide length which retains full activity in releasing serotonin from human platelets.
溶解度
分子量 680.8
化学式 C34H48N8O7
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents (Ala1)-PAR-4 (1-6)) amide (mouse)|[Ala1]-Protease Activated Receptor-4 (1-6) amide, mouse 编码 [352017-71-1]
Figures (Ala1)-PAR-4 (1-6)) amide (mouse)|[Ala1]-Protease Activated Receptor-4 (1-6) amide, mouse 编码 [352017-71-1]
Reference T.R.Faruqi et al., J. Biol. Chem., 275, 19728 (2000) M.D.Hollenberg and M.Saifeddine, Can. J. Physiol. Pharmacol., 79, 439 (2001) R.A.Henriksen and V.K.Hanks, Arterioscler. Thromb. Vasc. Biol., 22, 861 (2002) Sabri, A. et al. J. Biol. Chem. 278, 11714 (2003) Ma, L. et al. Proc. Natl. Acad. Sci. USA 102, 216 (2005)
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多肽定制[Ala1]-Protease Activated Receptor-4|(Ala1)-PAR-4 (1-6)) (mouse) 编码 [380900-00-5]

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名称 [Ala1]-Protease Activated Receptor-4|(Ala1)-PAR-4 (1-6)) (mouse)
编码 [380900-00-5]
别名 [Ala1]-Protease Activated Receptor-4|(Ala1)-PAR-4 (1-6)) (mouse)
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） AYPGKF
序列（三字母缩写） H-Ala-Tyr-Pro-Gly-Lys-Phe-OH (trifluoroacetate salt)
基本描述 Tethered ligand sequence of human PAR-4.
溶解度
分子量 681.79
化学式 C34H47N7O8
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents [Ala1]-Protease Activated Receptor-4|(Ala1)-PAR-4 (1-6)) (mouse) 编码 [380900-00-5]
Figures [Ala1]-Protease Activated Receptor-4|(Ala1)-PAR-4 (1-6)) (mouse) 编码 [380900-00-5]
Reference P.André et al., J. Clin. Invest., 112, 398 (2003) D.Woulfe et al., J. Clin. Invest., 113, 441 (2004) E.A. Lidington, et al., Am J Physiol Cell Physiol, 289, C1437 (2005) M.D. Hollenberg, et al., Pharmacol., 143, 443 (2004)
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多肽定制PAR – 1 Agonist;Protease – Activated Recep,Protease Activated Receptor-1-selective peptide 编码

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名称 PAR – 1 Agonist;Protease – Activated Recep,Protease Activated Receptor-1-selective peptide
编码
别名 PAR – 1 Agonist;Protease – Activated Recep,Protease Activated Receptor-1-selective peptide
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） TFLLRN
序列（三字母缩写） H-Thr-Phe-Leu-Leu-Arg-Asn-OH (trifluoroacetate salt)
基本描述 PAR1 Agonist.
溶解度
分子量 762.9
化学式 C35H58N10O9
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents PAR - 1 Agonist;Protease - Activated Recep,Protease Activated Receptor-1-selective peptide 编码
Figures PAR - 1 Agonist;Protease - Activated Recep,Protease Activated Receptor-1-selective peptide 编码
Reference Syeda,, F. et al. J. Biol. Chem 281, 11792 (2006) Jenkins, R. et al. J. Clin. Invest 116, 1606 (2006)
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多肽定制PAR-1,Protease Activated Receptor-1(1-6)) (mouse, rat) 编码 [140436-67-5]

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名称 PAR-1,Protease Activated Receptor-1(1-6)) (mouse, rat)
编码 [140436-67-5]
别名 PAR-1,Protease Activated Receptor-1(1-6)) (mouse, rat)
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） SFFLRN
序列（三字母缩写） H-Ser-Phe-Phe-Leu-Arg-Asn-OH (trifluoroacetate salt)
基本描述 This peptide inhibited activation of PAR-2 by trypsin in PAR-2 receptor expressing KNRK cells. Half-maximal inhibition of calcium signaling was observed at about 50 碌M. In contrast, the activation of PAR-2 by SLIGRL-NH2 (PAR-2 (1-6) amide (mouse, rat)) was not inhibited by this peptide. Selective Antagonist for PAR2 Agonist. This peptide blocks trypsin but not SLIGRL-NH2 activation of PAR2 in receptor-expressing KNRK cells.
溶解度
分子量 782.9
化学式 C37H54N10O9
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents PAR-1,Protease Activated Receptor-1(1-6)) (mouse, rat) 编码 [140436-67-5]
Figures PAR-1,Protease Activated Receptor-1(1-6)) (mouse, rat) 编码 [140436-67-5]
Reference Z.Suo et al., J. Biol. Chem., 278, 37681 (2003) P.J.Yu et al., Oncogene, 27, 2594 (2008) F.Bock et al., Proc. Natl. Acad. Sci. USA, 110, 648 (2013)
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多肽定制PAR-2 (1-6)) amide (human)) (scrambled) 编码

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名称 PAR-2 (1-6)) amide (human)) (scrambled)
编码
别名 PAR-2 (1-6)) amide (human)) (scrambled)
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） LSIGKV-NH2
序列（三字母缩写） H-Leu-Ser-Ile-Gly-Lys-Val-NH2?(trifluoroacetate salt)
基本描述 The peptide T1 is the thrombin receptor domain, which functions as a tethered ligand for the receptor itself. T1 is an inhibitor of thrombin triggered platelet aggregation, serotonin release and tyrosine phosphorylation. Its anti-aggregatory activity was about ten-fold higher than that of the previously reported peptide antagonists of the thrombin receptor. This peptide has served as model peptide in protein modification and MS studies.
溶解度
分子量 614.79
化学式 C28H54N8O7
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents PAR-2 (1-6)) amide (human)) (scrambled) 编码
Figures PAR-2 (1-6)) amide (human)) (scrambled) 编码
Reference H.Nishikawa et al., J. Pharmacol. Exp. Ther., 312, 324 (2005) I.A. Akers et al.,Am. J. Physiol. Lung Cell. Mol. Physiol., 278, L193 (2000) S. Miyata, et al., J. Biol. Chem., 275, 4592 (2000) S. Miike, A.S. McWilliam, and H. Kita, J. Immunol., 167, 6615 (2001)
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多肽定制PAR-2 (1-6),Protease Activated Receptor-2 (1-6), (mouse, rat) 编码 [164081-25-8]

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名称 PAR-2 (1-6),Protease Activated Receptor-2 (1-6), (mouse, rat)
编码 [164081-25-8]
别名 PAR-2 (1-6),Protease Activated Receptor-2 (1-6), (mouse, rat)
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） SLIGRL
序列（三字母缩写） H-Ser-Leu-Ile-Gly-Arg-Leu-OH (trifluoroacetate salt)
基本描述 The peptide is a protease-activated receptor-2 (PAR2) selective agonist.
溶解度
分子量 657.81
化学式 C29H55N9O8
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents PAR-2 (1-6),Protease Activated Receptor-2 (1-6), (mouse, rat) 编码 [164081-25-8]
Figures PAR-2 (1-6),Protease Activated Receptor-2 (1-6), (mouse, rat) 编码 [164081-25-8]
Reference R.J.Santulli et al., Proc. Natl. Acad. Sci. USA, 92, 9151 (1995) A. Bhattacharya et al., J. Pharmacol. Exp. Ther., 297, 573 (2001) B. Al-Ani, et al., J. of Physiol. Pharmacol., 73, 1203 (1995)
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多肽定制PAR-2 (1-6),Protease Activated Receptor-2 (1-6),amide (mouse, rat) 编码 [171436-38-7]

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名称 PAR-2 (1-6),Protease Activated Receptor-2 (1-6),amide (mouse, rat)
编码 [171436-38-7]
别名 PAR-2 (1-6),Protease Activated Receptor-2 (1-6),amide (mouse, rat)
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） SLIGRL-NH2
序列（三字母缩写） H-Ser-Leu-Ile-Gly-Arg-Leu-NH2?(trifluoroacetate salt)
基本描述 This peptide mimicks the putative tethered ligand of human PAR-3 (protease activated receptor 3). PAR3 Tethered Ligand (Human) / Activates PAR1 and PAR2
溶解度
分子量 656.83
化学式 C29H56N10O7
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents PAR-2 (1-6),Protease Activated Receptor-2 (1-6),amide (mouse, rat) 编码 [171436-38-7]
Figures PAR-2 (1-6),Protease Activated Receptor-2 (1-6),amide (mouse, rat) 编码 [171436-38-7]
Reference B.al-Ani et al., Can. J. Physiol. Pharmacol., 73, 1203 (1995) M.D.Hollenberg et al., Mol. Pharmacol., 49, 229 (1996) M.Saiffeddine et al., Br. J. Pharmacol., 118, 521 (1996) N.Vergnolle, J. Immunol., 163, 5064 (1999) B.Al-Ani et al., Br. J. Pharmacol., 128, 1105 (1999) E.R.Sharlow et al., J. Cell Sci., 113, 3093 (2000)
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多肽定制PAR-3 (1-6),Protease Activated Receptor-3 (1-6), human 编码 [320347-28-2]

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名称 PAR-3 (1-6),Protease Activated Receptor-3 (1-6), human
编码 [320347-28-2]
别名 PAR-3 (1-6),Protease Activated Receptor-3 (1-6), human
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） TFRGAP
序列（三字母缩写） H-Thr-Phe-Arg-Gly-Ala-Pro-OH (trifluoroacetate salt)
基本描述 This peptide is a human PAR-3-derived tethered ligand, which does not activate PAR-3 but rather activates PAR-1 and PAR-2, either in Jurkat or in other PAR-expressing cells. PAR3 Tethered Ligand (Human) / Activates PAR1 and PAR2 This peptide is the 1-6 fragment of the protease-activated receptor 3 (PAR-3), which induces ERK activation in human carcinoma cells endogeneously expressing PAR1 and PAR3. This effect is completely abolished by single alanine substitution at positions 3, 4 and 6 in the peptide. PAR-3 allosterically regulates PAR1 signaling by receptor dimerization governing increased endothelial permeability. Targeting of PAR3 may mitigate the effects of PAR1 in activating endothelial responses such as vascular inflammation. However this peptide does not affect VEGF release or expression.
溶解度
分子量 647.73
化学式 C29H45N9O8
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents PAR-3 (1-6),Protease Activated Receptor-3 (1-6), human 编码 [320347-28-2]
Figures PAR-3 (1-6),Protease Activated Receptor-3 (1-6), human 编码 [320347-28-2]
Reference H.Ishihara et al., Nature, 386, 502 (1997) K.K. Hansen et al., Immunology, 112, 183 (2004)
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多肽定制PAR-3 (1-6)Protease Activated Receptor-3 (1-6) amide, human 编码

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名称 PAR-3 (1-6)Protease Activated Receptor-3 (1-6) amide, human
编码
别名 PAR-3 (1-6)Protease Activated Receptor-3 (1-6) amide, human
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） TFRGAP-NH2
序列（三字母缩写） H-Thr-Phe-Arg-Gly-Ala-Pro-NH2?(trifluoroacetate salt)
基本描述 This peptide is a murine PAR-3-derived tethered ligand sequence which does not activate PAR-3, but rather activates PAR-1 and PAR-2, either in Jurkat T-cells or in other PAR-expressing cells. PAR3 Tethered Ligand (Murine) / Activates PAR1 and PAR2
溶解度
分子量 646.75
化学式 C29H46N10O7
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents PAR-3 (1-6)Protease Activated Receptor-3 (1-6) amide, human 编码
Figures PAR-3 (1-6)Protease Activated Receptor-3 (1-6) amide, human 编码
Reference K.K.Hansen et al., Immunology, 112, 183 (2004) Kaufmann, R. et al. Regul. Pept. 125, 61( 2005) McLaughlin, J. et al. PNAS 104, 5662 (2007) Arisato, T. et al. Cell. Mol. Life Sci. 60, 1420 (2003)
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多肽定制PAR-3 ,Protease Activated Receptor-3(1-6)) amide (mouse) 编码 [261521-21-5]

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名称 PAR-3 ,Protease Activated Receptor-3(1-6)) amide (mouse)
编码 [261521-21-5]
别名 PAR-3 ,Protease Activated Receptor-3(1-6)) amide (mouse)
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） SFNGGP-NH2
序列（三字母缩写） H-Ser-Phe-Asn-Gly-Gly-Pro-NH2?(trifluoroacetate salt)
基本描述 This peptide is the amino terminus of the fourth protease-activated receptor (PAR4) after the cleavage at Arg47/Gly48 was tested for its ability to stimulate COS cells expressing PAR4. The peptide readily activated both wild-type and mutant PAR4 (R47A) at 500 碌M, whereas thrombin and trypsin only activate the wild-type PAR4.
溶解度
分子量 576.61
化学式 C25H36N8O8
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents PAR-3 ,Protease Activated Receptor-3(1-6)) amide (mouse) 编码 [261521-21-5]
Figures PAR-3 ,Protease Activated Receptor-3(1-6)) amide (mouse) 编码 [261521-21-5]
Reference K.K.Hansen et al., Immunology, 112, 183 (2004)
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多肽定制PAR-4 (1-6)) amide |Protease Activated Receptor-4 (1-6) amide, human 编码 [245443-51-0]

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名称 PAR-4 (1-6)) amide |Protease Activated Receptor-4 (1-6) amide, human
编码 [245443-51-0]
别名 PAR-4 (1-6)) amide |Protease Activated Receptor-4 (1-6) amide, human
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） GYPGQV-NH2
序列（三字母缩写） H-Gly-Tyr-Pro-Gly-Gln-Val-NH2
基本描述 Protease-activated receptor-4 activating peptide derived from murine PAR-4. This peptide was able to cause rat platelet aggregation with an EC50 value of 40 碌M. Its effect on leucocyte rolling and adherence points at a role of PAR-4 in mediating proinflammatory processes. The family of at least seven transmembrane G protein coupled receptors includes at least four receptor subtypes (PAR1, PAR2, PAR3, PAR4). PAR4 activating peptides, GYPGKF-NH2 and AYPGKG-NH2, produce concentration dependent contractile effects on the muscle.
溶解度
分子量 618.69
化学式 C28H42N8O8
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents PAR-4 (1-6)) amide |Protease Activated Receptor-4 (1-6) amide, human 编码 [245443-51-0]
Figures PAR-4 (1-6)) amide |Protease Activated Receptor-4 (1-6) amide, human 编码 [245443-51-0]
Reference M.D.Hollenberg et al., Can. J. Physiol. Pharmacol., 77, 458 (1999) M.Tognetto et al., Br. J. Pharmacol., 139, 21 (2003) M.D.Hollenberg and S.Houle, Swiss Med. Wkly., 135, 425 (2005)
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多肽定制PAR-4 (1-6)) amide |Protease Activated Receptor-4 (1-6) amide, mouse 编码 [245443-52-1]

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上海金畔生物科技有限公司可以定制不同序列多肽，可以访问官网了解更多产品信息。

名称 PAR-4 (1-6)) amide |Protease Activated Receptor-4 (1-6) amide, mouse
编码 [245443-52-1]
别名 PAR-4 (1-6)) amide |Protease Activated Receptor-4 (1-6) amide, mouse
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） GYPGKF-NH2
序列（三字母缩写） H-Gly-Tyr-Pro-Gly-Lys-Phe-NH2?(trifluoroacetate salt)
基本描述 This peptide based on the proteolytically-revealed tethered ligand sequence of the murine proteinase-activated receptor-4 (PAR-4) was shown to cause platelet aggregation with an EC50 value of about 15 碌M. PAR-4 agonist peptide stimulates thromboxane production by human platelets with the maximal response to this agonist being approximately half of that observed after maximal thrombin stimulation.
溶解度
分子量 666.78
化学式 C33H46N8O7
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents PAR-4 (1-6)) amide |Protease Activated Receptor-4 (1-6) amide, mouse 编码 [245443-52-1]
Figures PAR-4 (1-6)) amide |Protease Activated Receptor-4 (1-6) amide, mouse 编码 [245443-52-1]
Reference N.Vergnolle, J. Immunol., 163, 5064 (1999) M.D.Hollenberg and M.Saifeddine, Can. J. Physiol. Pharmacol., 79, 439 (2001) Fang, J. et al. Blood 106, 2671(2005) Mulè, F. et al. Gut. 53, 229 (2004) Sekiguchi, F. et al. Drug Design Rev. 1, 287 (2004) Faruqi, T. et al. J. Biol. Chem. 275, 19728 (2000) Greenberg, D. Biochem. 42, 2702 (2003)
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多肽定制PAR-4 (1-6)) |Protease Activated Receptor-4 (1-6), human 编码 [225779-44-2]

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上海金畔生物科技有限公司可以定制不同序列多肽，可以访问官网了解更多产品信息。

名称 PAR-4 (1-6)) |Protease Activated Receptor-4 (1-6), human
编码 [225779-44-2]
别名 PAR-4 (1-6)) |Protease Activated Receptor-4 (1-6), human
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） GYPGQV
序列（三字母缩写） H-Gly-Tyr-Pro-Gly-Gln-Val-OH (trifluoroacetate salt)
基本描述 This PAR-4 activating peptide caused secretion and aggregation of PAR-3 deficient mouse platelets.
溶解度
分子量 619.68
化学式 C28H41N7O9
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents PAR-4 (1-6)) |Protease Activated Receptor-4 (1-6), human 编码 [225779-44-2]
Figures PAR-4 (1-6)) |Protease Activated Receptor-4 (1-6), human 编码 [225779-44-2]
Reference W.-F.Xu et al., Proc. Natl. Acad. Sci. USA, 95, 6642 (1998) H.Andersen et al., Proc. Natl. Acad. Sci. USA, 96, 11189 (1999) R.Kaufmann et al., J. Cancer Res. Clin. Oncol., 126, 91 (2000)
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多肽定制PAR-4 (1-6))|Protease Activated Receptor-4 (1-6), mouse 编码 [213018-42-9]

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上海金畔生物科技有限公司可以定制不同序列多肽，可以访问官网了解更多产品信息。

名称 PAR-4 (1-6))|Protease Activated Receptor-4 (1-6), mouse
编码 [213018-42-9]
别名 PAR-4 (1-6))|Protease Activated Receptor-4 (1-6), mouse
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） GYPGKF
序列（三字母缩写） H-Gly-Tyr-Pro-Gly-Lys-Phe-OH (trifluoroacetate salt)
基本描述
溶解度
分子量 667.76
化学式 C33H45N7O8
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents PAR-4 (1-6))|Protease Activated Receptor-4 (1-6), mouse 编码 [213018-42-9]
Figures PAR-4 (1-6))|Protease Activated Receptor-4 (1-6), mouse 编码 [213018-42-9]
Reference M.L.Kahn et al., Nature, 394, 690 (1998)
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多肽定制Protease – Activated Receptor – 1, PAR – 1 编码

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上海金畔生物科技有限公司可以定制不同序列多肽，可以访问官网了解更多产品信息。

名称 Protease – Activated Receptor – 1, PAR – 1
编码
别名 Protease – Activated Receptor – 1, PAR – 1
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） TFLLRNPNDK-NH2
序列（三字母缩写） H-Thr-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-NH2?(trifluoroacetate salt)
基本描述
溶解度
分子量 1216.4
化学式 C54H89N17O15
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents Protease - Activated Receptor - 1, PAR - 1 编码
Figures Protease - Activated Receptor - 1, PAR - 1 编码
Reference B.D. Blackhart, K. Emilsson, D. Nguyen, W. Teng, A.J. Martelli, S. Nystedt, J. Sundelin,and R.M. Scarborough, J. Biol. Chem., 271, 16466 (1996)
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