KAMIYA PC-543 说明书
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| 抗体 |
| 产品 |
克隆 |
主办 |
反应 |
应用 |
数量 |
货号 |
| LSD1（IN），（赖氨酸特异性组蛋白脱甲基酶） |
多克隆 |
兔子 |
人，老鼠，老鼠 |
蛋白质印迹 |
100μg |
PC-543 |
品名: Anti-LSD1 pAb
货号: PC-543 (100 µg)
Synonyms:Anti-Lysine-Specific Histone Demethylase, anti-Amine Oxidase Flavin Containing Domain Protein 2, anti-AOF2.
Format:100 µg of polyclonal antibody in PBS containing
0.02% sodium azide. Purified by immunoaffinity chromatography.
Background:
Histone modifications mediate changes in gene expression by altering chromatin structure or by serving as a platform to recruit other proteins. LSD1 is a recently discovered amine oxidase that catalyzes the lysine-specific demethylation of histone proteins via an FAD-dependent oxidative reaction. Methylation on histone H3-K9 is thought to play an important role in heterochromatin formation, while methylation on arginine and some lysine residues (such as H3-K4) is associated with active transcription. LSD1 associates with various proteins, including HDAC1/2, CoREST, and BHC80, that act to regulate LSD1 activity in vivo, and in a histone H3-K4-specific methylase complex that is involved in transcriptional regulation. Experiments have shown that CoREST, a SANT domain-containing co-repressor acts to enhance LSD1 activity, while BHC80, a PHD domain-containing protein, inhibits CoREST/LSD1 activity in vitro. LSD1-mediated histone demethylation thus may have significant effects on gene expression.
Storage: Store at 4°C.
Applications and Suggested Dilutions: Western blot: Use at 1 – 2 µg/mL.
Immunohistochemistry: Use at ~ 2 µg/mL.
The optimal dilution for a specific application should be determined by the researcher.
Figure 1: Western blot analysis of LSD1 in P815 cell lysate with anti-LSD1 pAb at (A) 1 µg/mL and (B) 2 µg/mL.
Specificity: Recognizes LSD1.
Positive Control: P815 cell lysate.
Species Reactivity:
Human, mouse and rat. Other species not tested.
Host: Rabbit
Immunogen:
Raised against a 16 amino acid peptide from near the center of human LSD1 (Genbank accession No. NP_001009999).
Figure 2: Immunohistochemistry of LSD1 in human small intestine tissue with LSD1 antibody at 2 µg/mL.
Limitations:For in vitro research use only. Not for use in diagnostics or in humans.
Warranty:
No warranties, expressed or implied, are made regarding the use of this product. KAMIYA BIOMEDICAL COMPANY is not liable for any damage,
personal injury, or economic loss caused by this product.
