Moradec Fab-αHFc-NC-MMAF说明书

Moradec Fab-αHFc-NC-MMAF说明书

 

Moradec LLC由Helen(Hongyuan)Mao博士于2012年创立,主要目标是为快速和经济的抗体 – 药物结合物发现提供新颖的研究工具。毛博士拥有超过14年的工业研发经验,包括主要制药公司,中小型生物技术公司。她近担任Fabrus的科学官,这是开发Fabrus Arrayed抗体筛选技术的关键。除了广泛的抗体优化专业知识外,她还积累了基于表皮生长因子受体的抗体治疗方法的丰富知识。在Fabrus之前,Mao博士领导了Biosite(现为Alere)抗体开发的蛋白质纯化组,先进的诊断公司,拥有用于开发诊断抗体的噬菌体展示平台技术。在Ansata Therapeutics,毛博士发明了基于分选酶的新型酶促蛋白质结合方法,该方法已经获得了研究应用,用于细胞表面标记,蛋白质阵列,核磁共振和蛋白质 – 药物结合等。毛医生进行了她的博士后诺华研究基金会(GNF)雅培实验室和基因组研究所的研究。她在麻省理工学院获得生物化学博士学位,在北京大学获得化学学士学位。毛在诺华研究基金会(GNF)的雅培实验室和基因组研究所进行了博士后研究。她在麻省理工学院获得生物化学博士学位,在北京大学获得化学学士学位。毛在诺华研究基金会(GNF)的雅培实验室和基因组研究所进行了博士后研究。她在麻省理工学院获得生物化学博士学位,在北京大学获得化学学士学位。

Moradec Fab-αHFc-NC-MMAF说明书

Fab-αHFc-NC-MMAF

FAB-αHFc-NC-MMAF

具有不可切割接头的Fab抗人IgG Fc-MMAF抗体

目录编号:AH-201-AF

Fab-αHFc-NC-MMAF是与具有不可切割接头的单甲基auristatin F(MMAF)缀合的抗人IgG Fc特异性抗体的Fab片段。抗体部分是对人IgG的Fc区特异的多克隆抗体Fab片段。单甲基auristatin F(MMAF)是一种细胞毒性小分子,通过阻断微管蛋白的聚合来抑制细胞分裂。连接MMAF与抗体的不可切割接头在细胞外液中是稳定的,但是在进入细胞时可以通过未的机制切割。Fab 2°ADC的单价性质在某些应用中可能比全长IgG 2°ADC具有一些优势。

 

 

二抗 – 药物偶联物目录

Moradec的新型二抗 – 药物偶联物(2°ADC)是预先筛选抗体导联作为ADC候选物的重要研究工具。“他们工作非常出色,而且没有主要的ab,它们的毒性极低!

 

 

具有可切割接头的IgGs抗人IgG Fc-PBD抗体

具有可切割接头的IgGs抗小鼠IgG Fc-PBD抗体

具有可切割接头的IgG抗兔IgG(H + L)-PBD抗体

Anti-Human IgG (Fc Specific)

IgGs Anti-Human IgG (Fc Specific) ADCs

Product Name

Description

Catalog No

QTY

Price

αHFc-NC-MMAF

IgGs Anti-Human IgG Fc-MMAF Antibody with Non-Cleavable Linker

AH-101AF-50

50µg

$330

AH-101AF-20

20µg

$165

αHFc-CL-MMAF

IgGs Anti-Human IgG Fc-MMAF Antibody with Cleavable Linker

AH-102AF-50

50µg

$330

AH-102AF-20

20µg

$165

αHFc-CL-MMAE

IgGs Anti-Human IgG Fc-MMAE Antibody with Cleavable Linker

AH-102AE-50

50µg

$330

AH-102AE-20

20µg

$165

αHFc-CL-DMSA

IgGs Anti-Human IgG Fc-Duocarmycin SA Antibody with Cleavable Linker

AH-102DS-50

50µg

$330

AH-102DS-20

20µg

$165

αHFc-CL-DMDM

IgGs Anti-Human IgG Fc-Duocarmycin DM Antibody with Cleavable Linker

AH-102DD-50

50µg

$330

AH-102DD-20

20µg

$165

αHFc-CL-PNU

IgGs Anti-Human IgG Fc-PNU159682 Antibody with Cleavable Linker

AH-102PN-50

50µg

$330

AH-102PN-20

20µg

$165

αHFc-NC-DM1

IgGs Anti-Human IgG Fc-DM1 Antibody with Non-Cleavable Linker

AH-103D1-50

50µg

$330

AH-103D1-20

20µg

$165

αHFc-CL-PBD

IgGs Anti-Human IgG Fc-PBD Antibody with Cleavable Linker

AH-106PB-50

50µg

$330

AH-106PB-20

20µg

$165

 

Fab Fragments of Anti-Human IgG (Fc Specific) ADCs

Product Name

Description

Catalog No

QTY

Price

Fab-αHFc-NC-MMAF

Fab Anti-Human IgG Fc-MMAF Antibody with Non-Cleavable Linker

AH-201AF-50

50µg

$440

AH-201AF-20

20µg

$220

Fab-αHFc-CL-MMAF

Fab Anti-Human IgG Fc-MMAF Antibody with Cleavable Linker

AH-202AF-50

50µg

$440

AH-202AF-20

20µg

$220

Fab-αHFc-CL-MMAE

Fab Anti-Human IgG Fc-MMAE Antibody with Cleavable Linker

AH-202AE-50

50µg

$440

AH-202AE-20

20µg

$220

Fab-αHFc-CL-DMSA

Fab Anti-Human IgG Fc-Duocarmycin SA Antibody with Cleavable Linker

AH-202DS-50

50µg

$440

AH-202DS-20

20µg

$220

Fab-αHFc-CL-DMDM

Fab Anti-Human IgG Fc-Duocarmycin DM Antibody with Cleavable Linker

AH-202DD-50

50µg

$440

AH-202DD-20

20µg

$220

Fab-αHFc-CL-PNU

Fab Anti-Human IgG Fc-PNU159682 Antibody with Cleavable Linker

AH-202PN-50

50µg

$440

AH-202PN-20

20µg

$220

Fab-αHFc-NC-DM1

Fab Anti-Human IgG Fc-DM1 Antibody with Non-Cleavable Linker

AH-203D1-50

50µg

$440

AH-203D1-20

20µg

$220

Fab-αHFc-NC-AAMT

Fab Anti-Human IgG Fc-Amanitin Antibody with Non-Cleavable Linker

AH-20M-50

50µg

$440

AH-20M-20

20µg

$220

 

Anti-Human IgG (Fab Specific)

IgGs Anti-Human IgG (Fab Specific) ADCs

Product Name

Description

Catalog No

QTY

Price

αHFab-NC-MMAF

IgGs Anti-Human IgG Fab-MMAF Antibody with Nonceavable Linker

AH-121AF-50

50µg

$360

AH-121AF-20

20µg

$180

αHFab-CL-MMAF

IgGs Anti-Human IgG Fab-MMAF Antibody with Cleavable Linker

AH-122AF-50

50µg

$360

AH-122AF-20

20µg

$180

αHFab-CL-MMAE

IgGs Anti-Human IgG Fab-MMAE Antibody with Cleavable Linker

AH-122AE-50

50µg

$360

AH-122AE-20

20µg

$180

αHFab-NC-DM1

IgGs Anti-Human IgG Fab-DM1 Antibody with Non-Cleavable Linker

AH-123D1-50

50µg

$360

AH-123D1-20

20µg

$180

 

Anti-Mouse IgG (Fc Specific)

IgGs Anti-Mouse IgG (Fc specific) ADCs

Product Name

Description

Catalog No

QTY

Price

αMFc-NC-MMAF

IgGs Anti-Mouse IgG Fc-MMAF Antibody with Non-Cleavable Linker

AM-101AF-50

50µg

$374

AM-101AF-20

20µg

$187

αMFc-CL-MMAF

IgGs Anti-Mouse IgG Fc-MMAF Antibody with Cleavable Linker

AM-102AF-50

50µg

$374

AM-102AF-20

20µg

$187

αMFc-CL-MMAE

IgGs Anti-Mouse IgG Fc-MMAE Antibody with Cleavable Linker

AM-102AE-50

50µg

$374

AM-102AE-20

20µg

$187

αMFc-CL-DMSA

IgGs Anti-Mouse IgG Fc-Duocarmycin SA Antibody with Cleavable Linker

AM-102DS-50

50µg

$374

AM-102DS-20

20µg

$187

αMFc-CL-DMDM

IgGs Anti-Mouse IgG Fc-Duocarmycin DM Antibody with Cleavable Linker

AM-102DD-50

50µg

$374

AM-102DD-20

20µg

$187

αMFc-CL-PNU

IgGs Anti-Mouse IgG Fc-PNU159682 Antibody with Cleavable Linker

AM-102PN-50

50µg

$374

AM-102PN-20

20µg

$187

αMFc-NC-DM1

IgGs Anti-Mouse IgG Fc-DM1 Antibody with Non-Cleavable Linker

AM-103D1-50

50µg

$374

AM-103D1-20

20µg

$187

αMFc-CL-PBD

IgGs Anti-Mouse IgG Fc-PBD Antibody with Cleavable Linker

AM-106PB-50

50µg

$374

AM-106PB-20

20µg

$187

Fab Fragments of Anti-Mouse IgG (Fc Specific) ADCs

Product Name

Description

Catalog No

QTY

Price

Fab-αMFc-NC-MMAF

Fab Anti-Mouse IgG Fc-MMAF Antibody with Non-Cleavable Linker

AM-201AF-50

50µg

$495

AM-201AF-20

20µg

$248

Fab-αMFc-CL-MMAF

Fab Anti-Mouse IgG Fc-MMAF Antibody with Cleavable Linker

AM-202AF-50

50µg

$495

AM-202AF-20

20µg

$248

Fab-αMFc-CL-MMAE

Fab Anti-Mouse IgG Fc-MMAE Antibody with Cleavable Linker

AM-202AE-50

50µg

$495

AM-202AE-20

20µg

$248

Fab-αMFc-CL-DMDM

Fab Anti-Mouse IgG Fc-duocarmycin DM Antibody with Cleavable Linker

AM-202DD-50

50µg

$495

AM-202DD-20

20µg

$248

Fab-αMFc-NC-DM1

Fab Anti-Mouse IgG Fc-DM1 Antibody with Noncleavable Linker

AM-203D1-50

50µg

$495

AM-203D1-20

20µg

$248

 

Anti-Rabbit IgG (Fc Specific)

IgGs Anti-Rabbit IgG (Fc Specific) ADCs

Product Name

Description

Catalog No

QTY

Price

αOFc-NC-MMAF

IgGs Anti-Rabbit IgG Fc-MMAF Antibody with Non-Cleavable Linker

AO-101AF-50

50µg

$396

AO-101AF-20

20µg

$198

Fab Fragments of Anti-Rabbit IgG (Fc Specific) ADCs

Product Name

Description

Catalog No

QTY

Price

Fab-αOFc-NC-MMAF

Fab Anti-Rabbit IgG Fc-MMAF Antibody with Non-Cleavable Linker

AO-201AF-50

50µg

$528

AO-201AF-20

20µg

$264

 

Anti-Rabbit IgG(H+L)

IgGs Anti-Rabbit IgG (H+L) ADCs

Product Name

Description

Catalog No

QTY

Price

αOIgG-NC-MMAF

IgGs Anti-Rabbit IgG(H+L)-MMAF Antibody with Non-Cleavable Linker

AO-111AF-50

50µg

$396

AO-111AF-20

20µg

$198

αOIgG-CL-MMAF

IgGs Anti-Rabbit IgG(H+L)-MMAF Antibody with Cleavable Linker

AO-112AF-50

50µg

$396

AO-112AF-20

20µg

$198

αOIgG-CL-MMAE

IgGs Anti-Rabbit IgG(H+L)-MMAE Antibody with Cleavable Linker

AO-112AE-50

50µg

$396

AO-112AE-20

20µg

$198

αOIgG-CL-PBD

IgGs Anti-Rabbit IgG(H+L)-PBD Antibody with Cleavable Linker

AO-116PB-50

50µg

$396

AO-116PB-20

20µg

$198

Fab Fragments of Anti-Rabbit IgG (H+L) ADCs

Product Name

Description

Catalog No

QTY

Price

Fab-αOIgG-NC-MMAF

Fab Anti-Rabbit IgG(H+L)-MMAF Antibody with Non-Cleavable Linker

AO-211AF-50

50µg

$528

AO-211AF-20

20µg

$264

Fab-αOIgG-CL-MMAF

Fab Anti-Rabbit IgG(H+L)-MMAF Antibody with Cleavable Linker

AO-212AF-50

50µg

$528

AO-212AF-20

20µg

$264

 

Anti-Rat IgG(Fc Specific)

IgGs Anti-Rat IgG (Fc Specific) ADCs

Product Name

Description

Catalog No

QTY

Price

αRFc-NC-MMAF

IgGs Anti-Rat IgG Fc-MMAF Antibody with Non-Cleavable Linker

AR-101AF-50

50µg

$396

AR-101AF-20

20µg

$198

αRFc-CL-MMAF

IgGs Anti-Rat IgG Fc-MMAF Antibody with Cleavable Linker

AR-102AF-50

50µg

$396

AR-102AF-20

20µg

$198

Fab Fragments of Anti-Rat IgG (Fc Specific) ADCs

Product Name

Description

Catalog No

QTY

Price

Fab-αRFc-NC-MMAF

Fab Anti-Rat IgG Fc-MMAF Antibody with Non-Cleavable Linker

AR-201AF-50

50µg

$528

AR-201AF-20

20µg

$264

Fab-αRFc-CL-MMAF

Fab Anti-Rat IgG Fc-MMAF Antibody with Cleavable Linker

AR-202AF-50

50µg

$528

AR-202AF-20

20µg

$264

Fab-αRFc-CL-MMAE

Fab Anti-Rat IgG Fc-MMAE Antibody with Cleavable Linker

AR-202AE-50

50µg

$528

AR-202AE-20

20µg

$264

Fab-αRFc-CL-DMDM

Fab Anti-Rat IgG Fc-Duocarmycin DM Antibody with Cleavable Linker

AR-202DD-50

50µg

$528

AR-202DD-20

20µg

$264

 

Anti-Rat IgG(H+L)

IgGs Anti-Rat IgG (H+L) ADCs

Product Name

Description

Catalog No

QTY

Price

αRIgG-NC-MMAF

IgGs Anti-Rat IgG(H+L)-MMAF Antibody with Non-Cleavable Linker

AR-111AF-50

50µg

$396

AR-111AF-20

20µg

$198

Fab Fragments of Anti-Rat IgG (H+L) ADCs

Product Name

Description

Catalog No

QTY

Price

Fab-αRIgG-NC-MMAF

Fab Anti-Rat IgG(H+L)-MMAF Antibody with Non-Cleavable Linker

AR-211AF-50

50µg

$528

AR-211AF-20

20µg

$264

Fab-αRIgG-CL-MMAF

Fab Anti-Rat IgG(H+L)-MMAF Antibody with Cleavable Linker

AR-212AF-50

50µg

$528

AR-212AF-20

20µg

$264

 

 

 

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