moradec—品牌介绍

moradec—品牌介绍

moradec

链接:https://moradec.com

Moradec LLCHelenHongyuanMao博士于2012年创立,主要目标是为快速经济的抗体药物偶联物发现提供新的研究工具,加速抗体药物共轭物(ADC)的发现,这是一种针对癌症的靶向治疗。它们的二级抗体药物共轭物(2°ADC)与各种细胞毒性药物如MMAEMMAFDM1Duocarmycin连接,为快速、经济有效的方式预筛选针对癌细胞具有相关作用机制的靶抗体提供了可能。由一种与细胞毒性药物连接的抗体组成,已成为一种新的针对癌症的靶向治疗方法。

抗体偶联物(ADC)由抗体与细胞毒性药物连接而成,通过单克隆抗体部分选择性地结合到目标癌细胞。内化后,药物释放出来作用于癌细胞,实现了对肿瘤细胞的特异性杀伤,同时极大程度减少了细胞毒性药物对全身的毒性。

在细胞基础的毒性试验中使用2°ADC消除了直接将每个单克隆抗体与细胞毒性药物偶联的必要性,节省了与纯化和偶联相关的时间和成本。通过在2°ADC存在的情况下直接将裸抗体添加到细胞中,可以实现类似于单克隆抗体药物共轭物中细胞内剂量依赖的药物释放效应,而不会影响表达目标受体水平较低的细胞。

Moradec2°ADC表现出高度特异性,在没有主要抗体的情况下对细胞毒性极小,并且在未结合的二级抗体存在的情况下保持主要抗体的活性。这种方法简化了ADC的开发过程,增强了筛选和选择用于靶向癌症治疗的最佳抗体药物共轭物的效率。

Moradec2°ADC具有高度特异性,在缺乏初级抗体的情况下对细胞的毒性最小。在存在未偶联的第二抗体的情况下,第一抗体活性没有明显变化。

Moradec2°ADC使得能够快速筛选主要抗体引物,以确定最佳候选者用于特定ADC的开发。提供了一系列具有可切割或不可切割连接子的2°ADC,有助于测试针对特定细胞系的多种药物连接子组合,以优化ADC格式。这些2°ADC也可应用于重组蛋白配体,用于靶向细胞表面受体。

部分产品信息

货号

产品名称

描述

规格

AH-101AF-50

αHFc-NC-MMAF

IgGs Anti-Human IgG Fc-MMAF Antibody with Non-Cleavable Linker

50µg

AH-103D1-50

αHFc-NC-DM1

IgGs Anti-Human IgG Fc-DM1 Antibody with Non-Cleavable Linker

50µg

AH-201AF-50

Fab-αHFc-NC-MMAF

Fab Anti-Human IgG Fc-MMAF Antibody with Non-Cleavable Linker

50µg

AH-121AF-50

αHFab-NC-MMAF

IgGs Anti-Human IgG Fab-MMAF Antibody with Nonceavable Linker

50µg

AM-101AF-50

αMFc-NC-MMAF

IgGs Anti-Mouse IgG Fc-MMAF Antibody with Non-Cleavable Linker

50µg

AO-101AF-50

αOFc-NC-MMAF

IgGs Anti-Rabbit IgG Fc-MMAF Antibody with Non-Cleavable Linker

50µg

更多其它产品详情请查询Moradec网站或咨询Moradec中国代理上海金畔生物。

Moradec热卖产品

货号

产品名称

规格

品牌

AH-102AE-50

αHFc-CL-MMAE

50μg

Moradec

AH-102AF-50

αHFc-CL-MMAF

50μg

Moradec

AH-202AE-50

Fab-αHFc-CL-MMAE

50μg

Moradec

AH-106PB-50

αHFc-CL-PBD

50μg

Moradec

AH-101AF-50

αHFc-NC-MMAF

50μg

Moradec

AH-107DX-50

αHFc-CL-DX8951

50μg

Moradec

AM-102AE-50

αMFc-CL-MMAE

50μg

Moradec

AH-207DX-50

Fab-αHFc-CL-DX8951

50μg

Moradec

AM-102AF-50

IgGs Anti-Mouse IgG Fc-MMAF Antibody with Cleavable Linker

50μg

Moradec

AH-202AF-50

Fab Anti-Human IgG Fc-MMAF Antibody with Cleavable Linker 50µg

50μg

Moradec

AH-122AE-50

IgGs Anti-Human IgG Fab-MMAE Antibody with Cleavable Linker 50µg

50μg

Moradec

AM-107DX-50

αMFc-CL-DX8951

50μg

Moradec

AM-202AE-50

Fab-αMFc-CL-MMAE

50μg

Moradec

AH-201AF-50

Fab-αHFc-NC-MMAF

50μg

Moradec

AM-106PB-50

αHFc-CL-PBD

50μg

Moradec

AH-102PN-50

αHFc-CL-PNU

50μg

Moradec

AH-202AE-20

Fab-αHFc-CL-MMAE

20μg

Moradec

AH-102AE-20

αHFc-CL-MMAE

20μg

Moradec

AM-103D1-50

IgGs Anti-Mouse IgG Fc-DM1 Antibody with Non-Cleavable Linker 50µg

50μg

Moradec

AM-202AE-20

Fab-αMFc-CL-MMAE

20μg

Moradec

AM-101AF-50

IgGs Anti-Mouse IgG FC-MMAF Antibody with Non-CleavableLinker

50μg

Moradec

AH-202DD-50

Fab Anti-Human IgG Fc-Duocarmycin DM Antibody with Cleavable Linker 50µg

50μg

Moradec

AH-103D1-50

IgGs Anti-Human IgG Fc-DM1 Antibody with Non-Cleavable Linker 50µg

50μg

Moradec

AM-201AF-50

Fab-αMFc-NC-MMAF

50μg

Moradec

AH-203D1-20

Fab Anti-Human IgG Fc-DM1 Antibody with Non-Cleavable Linker 20µg

20μg

Moradec

AM-203D1-20

Fab Anti-Mouse IgG Fc-DM1 Antibody with Noncleavable Linker 20µg

20μg

Moradec

AM-107DX-20

IgGs Anti-Mouse IgG Fc-DX8951 Antibody with Cleavable Linker 20µg

20μg

Moradec

AM-203D1-50

Fab-αMFc-NC-DM1

50μg

Moradec

AO-112AE-20

IgGs Anti-Rabbit IgG(H+L)-MMAE Antibody with Cleavable Linker 20µg

20μg

Moradec

AO-112AE-50

IgGs Anti-Rabbit IgG(H+L)-MMAE Antibody with Cleavable Linker 50µg

50μg

Moradec

AM-103D1-20

IgGs Anti-Mouse IgG Fc-DM1 Antibody with Non-Cleavable Linker 20µg

20μg

Moradec

AM-102AE-20

αMFc-CL-MMAE

20μg

Moradec

AM-102-AE-50

αMFc-CL-MMAE

50μg

Moradec

AH-207DX-20

Fab Anti-human IgG Fc-DX8951 Antibody with Cleavable Linker 20µg

20μg

Moradec

AH-202-AE

Fab-αHFc-CL-MMAE

ea

Moradec

AH-122AF-50

IgGs Anti-Human IgG Fab-MMAF Antibody with Cleavable Linker 50µg

50μg

Moradec

AH-102-AE

αHFc-CL-MMAE

ea

Moradec

AH-123D1-50

IgGs Anti-Human IgG Fab-DM1 Antibody with Non-Cleavable Linker 50µg

50μg

Moradec

AH-121AF-50

IgGs Anti-Human IgG Fab-MMAF Antibody with Nonceavable Linker 50µg

50μg

Moradec

AH-102AF-20

IgGs Anti-Human IgG Fc-MMAF Antibody with Cleavable Linker 20µg

20μg

Moradec

AH-102AE-50

αHFc-CL-MMAE

50μg

Moradec

AH-102AF-50

αHFc-CL-MMAF

50μg

Moradec

AH-202AE-50

Fab-αHFc-CL-MMAE

50μg

Moradec

AH-106PB-50

αHFc-CL-PBD

50μg

Moradec

AH-101AF-50

αHFc-NC-MMAF

50μg

Moradec

AH-107DX-50

αHFc-CL-DX8951

50μg

Moradec

AM-102AE-50

αMFc-CL-MMAE

50μg

Moradec

AH-207DX-50

Fab-αHFc-CL-DX8951

50μg

Moradec

AM-102AF-50

IgGs Anti-Mouse IgG Fc-MMAF Antibody with Cleavable Linker

50μg

Moradec

AH-202AF-50

Fab Anti-Human IgG Fc-MMAF Antibody with Cleavable Linker 50µg

50μg

Moradec